Dual PPARα/γ activation inhibitsSIRT1-PGC1α axis and causes cardiac dysfunction
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چکیده
منابع مشابه
PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction
BACKGROUND Inflammatory cytokines play an important role in the pathogenesis of heart failure. We have recently found the cytokine TWEAK (tumor necrosis factor (TNF)-like weak inducer of apoptosis), a member of the TNF superfamily, to be increased in patients with cardiomyopathy and result in the development of heart failure when overexpressed in mice. The molecular mechanisms underlying TWEAK-...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2019
ISSN: 2379-3708
DOI: 10.1172/jci.insight.129556